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ex 527, thermo scientific chemicals

ex 527, thermo scientific chemicals

CAS :

49843-98-3

Color :

White

Molecular Formula :

C13H13ClN2O

Quantity :

10 mg

MDL Number :

MFCD03009471

Synonym :

selisistat,sirt1 inhibitor iii,1h-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro,6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide, racemic,selisistat inn,6-chloro-1,2,3,4,9-pentahydro-4ah-carbazolecarboxamide,ex-527 selisistat,ex 527 selisistat,d0e3lp,cambridge id 6859180

Solubility Information :

Soluble in dimethyl sulfoxide,ethanol and dimethyl formamide.

InChI Key :

FUZYTVDVLBBXDL-UHFFFAOYSA-N

Description :

EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.

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ex 527, thermo scientific chemicals

49843-98-3

White

C13H13ClN2O

10 mg

MFCD03009471

selisistat,sirt1 inhibitor iii,1h-carbazole-1-carboxamide, 6-chloro-2,3,4,9-tetrahydro,6-chloro-2,3,4,9-tetrahydro-1h-carbazole-1-carboxamide, racemic,selisistat inn,6-chloro-1,2,3,4,9-pentahydro-4ah-carbazolecarboxamide,ex-527 selisistat,ex 527 selisistat,d0e3lp,cambridge id 6859180

Soluble in dimethyl sulfoxide,ethanol and dimethyl formamide.

FUZYTVDVLBBXDL-UHFFFAOYSA-N

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N(alpha)-Boc-D-2,3-diaminopropionic acid, 97%, Thermo Scientific Chemicals

2'-Aminoacetanilide, 98%, Thermo Scientific Chemicals

2,2,3,3-Tetrafluorocyclobutanol, 95%, Thermo Scientific Chemicals

4-Chloro-1-butanol, 85%, balance THF and HCl, Thermo Scientific Chemicals

n-Butylbenzene, 99+%, Thermo Scientific Chemicals

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