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kn-62, thermo scientific chemicals

kn-62, thermo scientific chemicals

Melting Point :

65°C to 67°C

Color :

Yellow

Linear Formula :

NH2(CH2)10NH2

Quantity :

10 mg

Solubility Information :

Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93mg/ml),methanol (10mg/ml),DMSO (12mg/ml),chloroform (20mg/ml),ethanol (∽1mg/ml),1:2 DMF:PBS (pH 7.2) (∽0.3mg/ml),and DMF & DMSO (∽30mg/ml).

Formula Weight :

721.84

Physical Form :

Powder

Chemical Name or Material :

KN-62

Description :

It is used as a potent and selective inhibitor of CaMKII. KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII; Ki=0.9 ?M) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 ?M of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM).

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kn-62, thermo scientific chemicals

65°C to 67°C

Yellow

NH2(CH2)10NH2

10 mg

Soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (0.93mg/ml),methanol (10mg/ml),DMSO (12mg/ml),chloroform (20mg/ml),ethanol (∽1mg/ml),1:2 DMF:PBS (pH 7.2) (∽0.3mg/ml),and DMF & DMSO (∽30mg/ml).

721.84

Powder

KN-62

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4-(4-Acetyl-1-piperazinyl)benzeneboronic acid pinacol ester, 95%, Thermo Scientific Chemicals

5-Amino-2,4,6-triiodoisophthalic acid, 95%, Thermo Scientific Chemicals

10-Hydroxydecanoic acid, 96%, Thermo Scientific Chemicals

Isopropyl formate, 98%, Thermo Scientific Chemicals

Tetra-n-hexylammonium hydrogen sulfate, 98%, Thermo Scientific Chemicals

Cyclopentanecarboxylic acid, 99%, Thermo Scientific Chemicals

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